Fenoldopam
Indications
Fenoldopam is used for:
Malignant Hypertension, Hypertensive Emergencies
Adult Dose
Severe/Malignant Hypertension, Hypertensive Emergencies
Initiate dosing at 0.01 to 0.3 mcg/kg/min by continuous IV infusion
Titrate by 0.05-0.1 mcg/kg/min q15min or longer until target blood pressure reached; up to 1.6 mcg/kg/min used in clinical trials; may continue maintenance infusion for up to 48 hr
In hospital use only
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to fenoldopam and sulfite
Precautions
Causes a dose-related tachycardia, particularly with infusion rates above 0.1 mcg/kg/min
Monitor potassium levels
Increased intraocular pressure in patients with glaucoma or intraocular hypertension
Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms in susceptible patients
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Excretion in milk unknown; use with caution
Interactions
Side Effects
Side effects of Fenoldopam :
Frequency Not Defined
Angina
Cardiac dysrhythmia
Dizziness
Flushing
Heart failure
Hypotension
Myocardial infarction
Tachycardia
Headache
Nausea
Vomiting
Serum creatinine raised
Mode of Action
D1-dopamine receptor agonist: rapid-acting vasodilator; decreases peripheral resistance and increases renal blood flow; has minimal adrenergic effects
Also diuretic, natriuretic